Explore flight options from Panama City to Medellín with competitive pricing starting from $170.
Panama City
PTY
→
Medellín
MDE
10/21/2025 – 10/28/2025
Cheap flight deals from Panama City to Medellín
Average price start from:
i
$238
Round-trip flights from Panama City to Medellín starting at $238. Book now for the best deals!
One-way from:
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$140
One-way flights from Panama City to Medellín starting at $140. Great for flexible travel!
Cheapest day:
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Tuesday
Tuesday is the cheapest day to fly from Panama City to Medellín. Save more by booking on this day!
Cheapest In:
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$86
Dec 2025
Dec 2025 is the cheapest month to fly from Panama City to Medellín with prices starting at $86.
Find flight deals from Panama City to Medellín
Cheapest flights from Panama City to Medellín
ONEWAY FLIGHTS
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Explore the cheapest oneway flights from Panama City to Medellín spotted daily.
PTY
Panama City
PTY - Panama City • 2025-10-21 • 09:00
Unknown
60 min
MDE
Unknown City
$140
Non-stop • 60 min
PTY
Panama City
PTY - Panama City • 2025-10-21 • 09:00
Unknown
60 min
MDE
Unknown City
$147
Non-stop • 60 min
Price Trends & Analysis
Weekly Price Trends
Optimal pricing available on Tuesday for flights to Medellín.
Monthly Price Trends
The cheapest month for flights from Panama City to Medellín is April.
Weather & Climate Information
Temperature
Rionegro has a subtropical highland climate, with mild temperatures year-round. Average daytime temperatures range from 17°C to 22°C (63°F to 72°F), with frequent rainfall, especially from April to November. Nights can be cool due to the city's elevation of over 2,100 meters (6,900 ft) above sea level.
Rainfall
The best time to visit Rionegro is during the dry season, from December to March, when rainfall is minimal and outdoor activities are more enjoyable.
Airlines at MDE
Book your journey from Panama City to Medellín with leading airlines including Avianca, Copa Airlines, Aeromexico, United Airlines. These carriers provide excellent connectivity and multiple daily options for convenient travel.
The typical flight time is about 10-15 hours, with most flights featuring one stopover for better pricing and route optimization. When traveling from Panama City to Medellín, these airlines ensure a smooth and comfortable experience with their modern fleet and professional service.
Places to Visit in Medellín
Top places to visit in Rionegro include the **Parque Principal de Rionegro**, The main square of Rionegro, surrounded by colonial architecture, cafes, and the historic Catedral de San Nicolás.; the **Catedral de San Nicolás**, A historic cathedral located in the heart of Rionegro, known for its neoclassical architecture and cultural significance.; the **Museo Histórico Casa de la Convención**, A museum housed in a colonial building where the 1863 Rionegro Constitution was signed, showcasing local history.; and the **Comfama Rionegro Park**, A large recreational park offering sports facilities, swimming pools, and family activities..
About Medellín
Travel to Medellín from Panama City for an unforgettable experience in this vibrant destination. Rionegro is a city in the Antioquia Department of Colombia, known for its proximity to Medellín and as the location of José María Córdova International Airport (MDE), the main international gateway for the Medellín metropolitan area. The city is surrounded by lush green hills and is a hub for both business and tourism in the region.[2][1]
Rionegro has colonial roots and played a significant role in Colombia's independence movement. The José María Córdova International Airport, named after a local independence hero, opened in 1985 and has since become the second largest airport in Colombia, serving as a major hub for both domestic and international travel.[1][2]
The best time to visit Medellín is during Peak travel season is December to January and during major Colombian holidays, when both tourism and flight traffic increase significantly., when the weather is most pleasant for outdoor activities.
For the best deals on flights from Panama City to Medellín, consider booking during April and flying on Tuesday. As you plan your trip, remember to explore the local culture and indulge in Medellín's culinary scene.
Airlines Flying from Panama City to Medellín
Book your journey from Panama City to Medellín with leading airlines including Avianca, Copa Airlines, Aeromexico, United Airlines. These carriers provide excellent connectivity and multiple daily options for convenient travel.
The typical flight time is about 10-15 hours, with most flights featuring one stopover for better pricing and route optimization. When traveling from Panama City to Medellín, these airlines ensure a smooth and comfortable experience with their modern fleet and professional service.
Hotels in Medellín
For accommodations near Medellín Airport (MDE), consider booking hotels in the city center or near the airport. Many hotels offer shuttle services to and from the airport for convenient travel.
Airport Statistics
As a premier transportation hub, the airport boasts extensive connectivity with multiple domestic and international routes, facilitating seamless passenger movement through its state-of-the-art terminal. Equipped with modern facilities, including efficient check-in systems, upscale lounges, and diverse retail and dining options, the airport ensures a superior travel experience for all passengers.
About Medellín
Travel to Medellín from Panama City for an unforgettable experience in this vibrant destination. Rionegro is a city in the Antioquia Department of Colombia, known for its proximity to Medellín and as the location of José María Córdova International Airport (MDE), the main international gateway for the Medellín metropolitan area. The city is surrounded by lush green hills and is a hub for both business and tourism in the region.[2][1]
Rionegro has colonial roots and played a significant role in Colombia's independence movement. The José María Córdova International Airport, named after a local independence hero, opened in 1985 and has since become the second largest airport in Colombia, serving as a major hub for both domestic and international travel.[1][2]
The best time to visit Medellín is during Peak travel season is December to January and during major Colombian holidays, when both tourism and flight traffic increase significantly., when the weather is most pleasant for outdoor activities.
For the best deals on flights from Panama City to Medellín, consider booking during April and flying on Tuesday. As you plan your trip, remember to explore the local culture and indulge in Medellín's culinary scene.
Places to Visit in Medellín
Top places to visit in Rionegro include the **Parque Principal de Rionegro**, The main square of Rionegro, surrounded by colonial architecture, cafes, and the historic Catedral de San Nicolás.; the **Catedral de San Nicolás**, A historic cathedral located in the heart of Rionegro, known for its neoclassical architecture and cultural significance.; the **Museo Histórico Casa de la Convención**, A museum housed in a colonial building where the 1863 Rionegro Constitution was signed, showcasing local history.; and the **Comfama Rionegro Park**, A large recreational park offering sports facilities, swimming pools, and family activities..
Hotels in Medellín
For accommodations near Medellín Airport (MDE), consider booking hotels in the city center or near the airport. Many hotels offer shuttle services to and from the airport for convenient travel.
Airlines Flying from Panama City to Medellín
Book your journey from Panama City to Medellín with leading airlines including Avianca, Copa Airlines, Aeromexico, United Airlines. These carriers provide excellent connectivity and multiple daily options for convenient travel.
The typical flight time is about 10-15 hours, with most flights featuring one stopover for better pricing and route optimization. When traveling from Panama City to Medellín, these airlines ensure a smooth and comfortable experience with their modern fleet and professional service.
Frequently Asked Questions
What's the best deal for flights from Panama City to Medellín?
The lowest fare available is $140. Maximize savings by booking during April and selecting Tuesday flights.
How many hours does it take to fly from Panama City to Medellín?
Flight duration typically ranges around 10-15 hours, with most flights including one stopover for optimal route efficiency.
Which carriers fly between Panama City and Medellín?
Major airlines serving this route include Avianca, Copa Airlines, Aeromexico. Each offers different schedules and amenities to suit various travel preferences.
What's the ideal booking window for this route?
Book 2-3 months in advance for the best prices. Traveling during April can provide additional savings opportunities.
Are there convenient hotels near MDE Airport?
Yes, MDE Airport is surrounded by hotels offering shuttle services and modern amenities for travelers.
Why should I visit Medellín?
Medellín offers an incredible mix of cultural experiences and modern attractions. Plan your visit during Peak travel season is December to January and during major Colombian holidays, when both tourism and flight traffic increase significantly. for the most enjoyable experience.
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