Book your flight from Medellín (MDE) to Cali (CLO) at the best prices. Fares start from $61.
Medellín
MDE
→
Cali
CLO
10/22/2025 – 10/29/2025
Cheap flight deals from Medellín to Cali
Average price start from:
i
$42
Round-trip flights from Medellín to Cali starting at $42. Book now for the best deals!
One-way from:
i
$24
One-way flights from Medellín to Cali starting at $24. Great for flexible travel!
Cheapest day:
i
Tuesday
Tuesday is the cheapest day to fly from Medellín to Cali. Save more by booking on this day!
Cheapest In:
i
$19
Apr 2025
Apr 2025 is the cheapest month to fly from Medellín to Cali with prices starting at $19.
Find flight deals from Medellín to Cali
Cheapest flights from Medellín to Cali
ONEWAY FLIGHTS
LAST MINUTE
CHEAP FLIGHTS
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Explore the cheapest oneway flights from Medellín to Cali spotted daily.
MDE
Medellín
MDE - Medellín • 2025-10-22 • 09:00
Unknown
60 min
CLO
Unknown City
$24
Non-stop • 60 min
MDE
Medellín
MDE - Medellín • 2025-10-22 • 09:00
Unknown
60 min
CLO
Unknown City
$30
Non-stop • 60 min
MDE
Medellín
MDE - Medellín • 2025-10-22 • 09:00
Unknown
60 min
CLO
Unknown City
$31
Non-stop • 60 min
Price Trends & Analysis
Weekly Price Trends
Optimal pricing available on Tuesday for flights to Cali.
Monthly Price Trends
Save the most on flights from Medellín to Cali in September.
Weather & Climate Information
Temperature
Palmira experiences a tropical climate with warm temperatures year-round. Average highs range from 28°C to 32°C (82°F to 90°F), and rainfall is most frequent from March to May and October to November.
Rainfall
The best time to visit Palmira is during the dry season, from June to September and December to February, when outdoor activities and festivals are most enjoyable.
Airlines at CLO
Discover excellent flight options from Medellín to Cali with top airlines including JetSMART, Avianca, LATAM Airlines Chile. These carriers offer reliable service and comfortable connections between these popular destinations.
The average flight time is approximately 10-15 hours, with most routes featuring one stopover for optimal pricing and convenience. When planning your journey from Medellín to Cali, these airlines provide excellent connectivity and modern aircraft for a pleasant travel experience.
Places to Visit in Cali
Top places to visit in Palmira include the **Museo Aereo Fenix**, Colombia's only civil aviation and railroad museum, featuring full-size aircraft, locomotives, model airports, and railroad layouts[2].; the **Reserva Natural Nirvana**, A nature reserve offering hiking trails, bird-watching, and a butterfly enclosure, ideal for outdoor enthusiasts[1][2].; the **Catedral de Nuestra Señora del Rosario del Palmar**, Historic cathedral and architectural landmark in the city center[2].; the **Plaza de Bolivar**, Central square featuring the Simon Bolivar statue and a large park, popular for relaxation and local events[4].; and the **Parque de la Factoría**, Emblematic urban park with green areas, bike paths, and local food fairs, famous for the cholado palmirano[3]..
About Cali
Travel to Cali from Medellín for an unforgettable experience in this vibrant destination. Palmira, known as the 'Agricultural Capital of Colombia,' is a vibrant city in Valle del Cauca surrounded by lush fields and natural beauty. It offers a unique blend of culture, history, and outdoor activities, making it ideal for nature lovers, history enthusiasts, and foodies[1][3].
Palmira has played a key role in Colombia's agricultural development, contributing significantly to the agro-industrial sector. Its strategic location near Cali and the Alfonso Bonilla Aragon International Airport has made it a hub for rural innovation and connectivity[3].
The best time to visit Cali is during Peak tourist season is typically from December to January and during Easter, coinciding with local holidays and festivals., when the weather is most pleasant for outdoor activities.
For the best deals on flights from Medellín to Cali, consider booking during September and flying on Tuesday. As you plan your trip, remember to explore the local culture and indulge in Cali's culinary scene.
Airlines Flying from Medellín to Cali
Discover excellent flight options from Medellín to Cali with top airlines including JetSMART, Avianca, LATAM Airlines Chile. These carriers offer reliable service and comfortable connections between these popular destinations.
The average flight time is approximately 10-15 hours, with most routes featuring one stopover for optimal pricing and convenience. When planning your journey from Medellín to Cali, these airlines provide excellent connectivity and modern aircraft for a pleasant travel experience.
Hotels in Cali
Accommodations near CLO Airport provide excellent connectivity for travelers visiting Cali. Look for hotels with shuttle services and modern amenities.
Airport Statistics
The airport serves as a critical transportation hub, offering extensive connectivity through multiple domestic and international flight routes, supported by an efficient ground transportation network including shuttles, taxis, and rail services. Boasting state-of-the-art facilities, passengers enjoy seamless experiences with amenities such as automated check-in kiosks, premium lounges, and diverse dining options, ensuring comfort and convenience throughout their journey.
About Cali
Travel to Cali from Medellín for an unforgettable experience in this vibrant destination. Palmira, known as the 'Agricultural Capital of Colombia,' is a vibrant city in Valle del Cauca surrounded by lush fields and natural beauty. It offers a unique blend of culture, history, and outdoor activities, making it ideal for nature lovers, history enthusiasts, and foodies[1][3].
Palmira has played a key role in Colombia's agricultural development, contributing significantly to the agro-industrial sector. Its strategic location near Cali and the Alfonso Bonilla Aragon International Airport has made it a hub for rural innovation and connectivity[3].
The best time to visit Cali is during Peak tourist season is typically from December to January and during Easter, coinciding with local holidays and festivals., when the weather is most pleasant for outdoor activities.
For the best deals on flights from Medellín to Cali, consider booking during September and flying on Tuesday. As you plan your trip, remember to explore the local culture and indulge in Cali's culinary scene.
Places to Visit in Cali
Top places to visit in Palmira include the **Museo Aereo Fenix**, Colombia's only civil aviation and railroad museum, featuring full-size aircraft, locomotives, model airports, and railroad layouts[2].; the **Reserva Natural Nirvana**, A nature reserve offering hiking trails, bird-watching, and a butterfly enclosure, ideal for outdoor enthusiasts[1][2].; the **Catedral de Nuestra Señora del Rosario del Palmar**, Historic cathedral and architectural landmark in the city center[2].; the **Plaza de Bolivar**, Central square featuring the Simon Bolivar statue and a large park, popular for relaxation and local events[4].; and the **Parque de la Factoría**, Emblematic urban park with green areas, bike paths, and local food fairs, famous for the cholado palmirano[3]..
Hotels in Cali
Accommodations near CLO Airport provide excellent connectivity for travelers visiting Cali. Look for hotels with shuttle services and modern amenities.
Airlines Flying from Medellín to Cali
Discover excellent flight options from Medellín to Cali with top airlines including JetSMART, Avianca, LATAM Airlines Chile. These carriers offer reliable service and comfortable connections between these popular destinations.
The average flight time is approximately 10-15 hours, with most routes featuring one stopover for optimal pricing and convenience. When planning your journey from Medellín to Cali, these airlines provide excellent connectivity and modern aircraft for a pleasant travel experience.
Frequently Asked Questions
What's the best deal for flights from Medellín to Cali?
The lowest fare available is $24. Maximize savings by booking during September and selecting Tuesday flights.
How many hours does it take to fly from Medellín to Cali?
Flight duration typically ranges around 10-15 hours, with most flights including one stopover for optimal route efficiency.
Which carriers fly between Medellín and Cali?
Major airlines serving this route include JetSMART, Avianca, LATAM Airlines Chile. Each offers different schedules and amenities to suit various travel preferences.
What's the ideal booking window for this route?
Book 2-3 months in advance for the best prices. Traveling during September can provide additional savings opportunities.
Are there convenient hotels near CLO Airport?
Yes, CLO Airport is surrounded by hotels offering shuttle services and modern amenities for travelers.
Why should I visit Cali?
Cali offers an incredible mix of cultural experiences and modern attractions. Plan your visit during Peak tourist season is typically from December to January and during Easter, coinciding with local holidays and festivals. for the most enjoyable experience.
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