Flights from Des Moines to Saint Louis from $59

Explore the cheapest oneway flights from Des Moines to Saint Louis spotted daily.

Traveling from Des Moines to Saint Louis has never been more convenient, thanks to several reputable airlines offering seamless connectivity between these vibrant cities. Airlines such as Southwest Airlines, Frontier Airlines, American Airlines, United Airlines provide regular flights, ensuring travelers have flexible options to suit their schedules. Typically, the flight duration is around 10-15 hours, depending on layovers and the chosen route. Most flights from Des Moines to Saint Louis include one stopover, often in major hubs, allowing for a comfortable transition. For those seeking to explore Saint Louis, booking with these airlines ensures a smooth travel experience, complete with modern amenities and excellent service.

Top places to visit in Saint Louis include the **Gateway Arch**, The tallest monument in the U.S., offering panoramic views of the city and Mississippi River.; the **Forest Park**, A sprawling urban park featuring museums, a zoo, and scenic walking trails.; the **Saint Louis Art Museum**, A renowned museum with extensive collections of art from around the world, located in Forest Park.; the **Saint Louis Zoo**, One of the top zoos in the country, offering free admission and a wide variety of animals.; and the **City Museum**, An eclectic, interactive museum housed in a former shoe factory, popular with families..

Experience the wonders of Saint Louis on your flight from Des Moines. Located in a fascinating region, this destination offers Saint Louis is a major city in Missouri, known for its iconic Gateway Arch, vibrant cultural scene, and rich history along the Mississippi River. Founded in 1764 by French fur traders, Saint Louis became a key port on the Mississippi River and played a significant role in westward expansion, notably as the starting point for the Lewis and Clark Expedition. The ideal time to explore Saint Louis is during Peak tourist season is summer (June to August), coinciding with school holidays and major festivals., when the climate is perfect for sightseeing and outdoor adventures. Get the best value for your money by booking flights from Des Moines to Saint Louis in November and opting for Thursday departures. Dive into the local culture and discover the culinary treasures of Saint Louis.

Traveling from Des Moines to Saint Louis has never been more convenient, thanks to several reputable airlines offering seamless connectivity between these vibrant cities. Airlines such as Southwest Airlines, Frontier Airlines, American Airlines, United Airlines provide regular flights, ensuring travelers have flexible options to suit their schedules. Typically, the flight duration is around 10-15 hours, depending on layovers and the chosen route. Most flights from Des Moines to Saint Louis include one stopover, often in major hubs, allowing for a comfortable transition. For those seeking to explore Saint Louis, booking with these airlines ensures a smooth travel experience, complete with modern amenities and excellent service.

Discover top-rated hotels near STL Airport for your stay in Saint Louis. These accommodations offer excellent connectivity to STL Airport and provide modern amenities for business and leisure travelers. Book early to secure the best rates and availability.