Flights from Des Moines (DSM) to Saint Louis (STL)

Plan your journey from Des Moines to Saint Louis with the latest deals, travel tips, and flight information.

Des Moines

DSM

→

Saint Louis

STL

From

09/21/2025 – 09/28/2025

Travelers & Class

Include hotels in search

Cheap flight deals from Des Moines to Saint Louis

Average price start from:

$272

Des Moines to Saint Louis

One-way from:

$59

Des Moines to Saint Louis

Cheapest day:

Thursday

Cheapest flights to Saint Louis on this day

Cheapest In:

November

Cheapest prices for flights to Saint Louis this month

Find flight deals from Des Moines to Saint Louis

Cheapest flights from Des Moines to Saint Louis

ONEWAY FLIGHTS

LAST MINUTE

CHEAP FLIGHTS

BEST FLIGHTS

Explore the cheapest oneway flights from Des Moines to Saint Louis spotted daily.

DSM

DSM - Des Moines • 2025-09-21 • 09:00

Unknown

60 min

STL

$59

Non-stop • 60 min

DSM

DSM - Des Moines • 2025-09-21 • 09:00

Unknown

60 min

STL

$80

Non-stop • 60 min

DSM

DSM - Des Moines • 2025-09-21 • 09:00

Unknown

60 min

STL

$89

Non-stop • 60 min

DSM

DSM - Des Moines • 2025-09-21 • 09:00

Unknown

60 min

ORD

Chicago

$95

Non-stop • 60 min

DSM

DSM - Des Moines • 2025-09-21 • 09:00

Unknown

60 min

ORD

Chicago

$105

Non-stop • 60 min

DSM

DSM - Des Moines • 2025-09-21 • 09:00

Unknown

60 min

ORD

Chicago

$110

Non-stop • 60 min

DSM

DSM - Des Moines • 2025-09-21 • 09:00

Unknown

60 min

STL

$114

Non-stop • 60 min

DSM

DSM - Des Moines • 2025-09-21 • 09:00

Unknown

60 min

ORD

Chicago

$124

Non-stop • 60 min

DSM

DSM - Des Moines • 2025-09-21 • 09:00

Unknown

60 min

ORD

Chicago

$131

Non-stop • 60 min

DSM

DSM - Des Moines • 2025-09-21 • 09:00

Unknown

60 min

MDW

$135

Non-stop • 60 min

DSM

DSM - Des Moines • 2025-09-21 • 09:00

Unknown

60 min

MDW

$140

Non-stop • 60 min

DSM

DSM - Des Moines • 2025-09-21 • 09:00

Unknown

60 min

RFD

$151

Non-stop • 60 min

Price Trends & Analysis

Weekly Price Trends

Track weekly price fluctuations for flights from Des Moines to Saint Louis. Prices typically vary by day of the week, with mid-week flights often offering better deals.

Monthly Price Trends

Monitor monthly price patterns to identify the best time to book your flight from Des Moines to Saint Louis. Seasonal variations and holiday periods significantly impact pricing.

Weather & Climate Information

Temperature

Plan your visit to Saint Louis with current temperature data. Saint Louis experiences varied weather throughout the year, with temperatures ranging from mild to warm depending on the season.

Rainfall

Stay prepared for your trip to Saint Louis with rainfall information. Understanding precipitation patterns helps you pack appropriately and plan outdoor activities during your visit.

Flights from Des Moines (DSM) to Saint Louis (STL)

Plan your journey from Des Moines to Saint Louis with the latest deals, travel tips, and flight information.

Des Moines

→

Saint Louis

Cheap flight deals from Des Moines to Saint Louis

Average price start from:

$272

One-way from:

$59

Cheapest day:

Thursday

Cheapest In:

November

Find flight deals from Des Moines to Saint Louis

Cheapest flights from Des Moines to Saint Louis

DSM

STL

$59

DSM

STL

$80

DSM

STL

$89

DSM

ORD

$95

DSM

ORD

$105

DSM

ORD

$110

DSM

STL

$114

DSM

ORD

$124

DSM

ORD

$131

DSM

MDW

$135

DSM

MDW

$140

DSM

RFD

$151

Price Trends & Analysis

Weekly Price Trends

Monthly Price Trends

Weather & Climate Information

Temperature

Rainfall

flight

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