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Flights from Des Moines to Santa Ana from $70

Explore flight options from Des Moines to Santa Ana with competitive pricing starting from $411.
Des Moines

DSM

→

Santa Ana

SNA

10/15/2025 – 10/22/2025

Cheap flight deals from Des Moines to Santa Ana

Average price start from:
i

$108

Round-trip flights from Des Moines to Santa Ana starting at $108. Book now for the best deals!

One-way from:
i

$70

One-way flights from Des Moines to Santa Ana starting at $70. Great for flexible travel!

Cheapest day:
i

Wednesday

Wednesday is the cheapest day to fly from Des Moines to Santa Ana. Save more by booking on this day!

Cheapest In:
i

$105

Sep 2025

Sep 2025 is the cheapest month to fly from Des Moines to Santa Ana with prices starting at $105.

Find flight deals from Des Moines to Santa Ana

Cheapest flights from Des Moines to Santa Ana

ONEWAY FLIGHTS

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Explore the cheapest oneway flights from Des Moines to Santa Ana spotted daily.

DSM

Des Moines

DSM - Des Moines • 2025-10-15 • 09:00

Unknown

60 min

SNA

Unknown City

$70

Non-stop • 60 min

DSM

Des Moines

DSM - Des Moines • 2025-10-15 • 09:00

Unknown

60 min

SNA

Unknown City

$169

Non-stop • 60 min

DSM

Des Moines

DSM - Des Moines • 2025-10-15 • 09:00

Unknown

60 min

SNA

Unknown City

$198

Non-stop • 60 min

DSM

Des Moines

DSM - Des Moines • 2025-10-15 • 09:00

Unknown

60 min

SNA

Unknown City

$204

Non-stop • 60 min

DSM

Des Moines

DSM - Des Moines • 2025-10-15 • 09:00

Unknown

60 min

SNA

Unknown City

$379

Non-stop • 60 min

Price Trends & Analysis

Monthly Price Trends

Save the most on flights from Des Moines to Santa Ana in June.

Weather & Climate Information

Temperature

Santa Ana experiences a Mediterranean climate with warm, dry summers and mild, wetter winters. Average summer highs are around 28°C (82°F), while winter highs average 20°C (68°F). Rain is most common from November to March.[3]

Rainfall

The best time to visit Santa Ana is from late spring to early fall (April to October), when the weather is warm and outdoor events are frequent.[3]

Airlines at SNA

Traveling from Des Moines to Santa Ana has never been more convenient, thanks to several reputable airlines offering seamless connectivity between these vibrant cities. Airlines such as Allegiant Air, Frontier Airlines, Southwest Airlines, American Airlines provide regular flights, ensuring travelers have flexible options to suit their schedules. Typically, the flight duration is around 10-15 hours, depending on layovers and the chosen route. Most flights from Des Moines to Santa Ana include one stopover, often in major hubs, allowing for a comfortable transition. For those seeking to explore Santa Ana, booking with these airlines ensures a smooth travel experience, complete with modern amenities and excellent service.

Places to Visit in Santa Ana

Top places to visit in Santa Ana include the **Bowers Museum**, A renowned museum featuring global art and cultural exhibits, including Asian, Native American, and pre-Columbian collections. It regularly hosts special exhibitions and family-friendly activities.[1][2][5]; the **Santa Ana Zoo**, A family-oriented zoo known for its collection of monkeys, exotic birds, and interactive farm experiences for children.[1][5]; the **Lyon Air Museum**, Aviation museum featuring World War II aircraft, military vehicles, and memorabilia, located adjacent to John Wayne Airport.[1][2]; the **Downtown Santa Ana / Artists Village**, A lively arts district with galleries, theaters, boutiques, and the Grand Central Art Center. Hosts monthly ArtWalk events and features vibrant street art.[3][5]; and the **Discovery Cube Orange County**, An interactive science museum with hands-on exhibits, a 4-D theater, and educational programs for children and families.[1].

About Santa Ana

Travel to Santa Ana from Des Moines for an unforgettable experience in this vibrant destination. Santa Ana is a vibrant city in Orange County, California, known for its rich cultural scene, diverse cuisine, and family-friendly attractions. The city features a walkable downtown with art galleries, theaters, and creative eateries, making it a lively destination for visitors of all ages.[3][4] Founded in 1869, Santa Ana has grown from a small agricultural community into the county seat and one of the most populous cities in Orange County. Its downtown area preserves historic architecture and has evolved into a hub for arts and culture, reflecting the city's diverse heritage.[3][4] The best time to visit Santa Ana is during Peak tourist season is during the summer months (June to August), coinciding with school vacations and numerous local festivals.[3], when the weather is most pleasant for outdoor activities. For the best deals on flights from Des Moines to Santa Ana, consider booking during June and flying on Wednesday. As you plan your trip, remember to explore the local culture and indulge in Santa Ana's culinary scene.

Airlines Flying from Des Moines to Santa Ana

Traveling from Des Moines to Santa Ana has never been more convenient, thanks to several reputable airlines offering seamless connectivity between these vibrant cities. Airlines such as Allegiant Air, Frontier Airlines, Southwest Airlines, American Airlines provide regular flights, ensuring travelers have flexible options to suit their schedules. Typically, the flight duration is around 10-15 hours, depending on layovers and the chosen route. Most flights from Des Moines to Santa Ana include one stopover, often in major hubs, allowing for a comfortable transition. For those seeking to explore Santa Ana, booking with these airlines ensures a smooth travel experience, complete with modern amenities and excellent service.

Hotels in Santa Ana

Accommodations near SNA Airport provide excellent connectivity for travelers visiting Santa Ana. Look for hotels with shuttle services and modern amenities.

Airport Statistics

As a premier transportation hub, the airport boasts extensive connectivity with domestic and international routes, efficiently accommodating both passenger and cargo operations through its state-of-the-art terminal infrastructure. Enhanced by modern facilities, including advanced check-in systems, lounges, and retail options, the airport ensures an exceptional passenger experience, prioritizing convenience and comfort throughout all stages of travel.

About Santa Ana

Travel to Santa Ana from Des Moines for an unforgettable experience in this vibrant destination. Santa Ana is a vibrant city in Orange County, California, known for its rich cultural scene, diverse cuisine, and family-friendly attractions. The city features a walkable downtown with art galleries, theaters, and creative eateries, making it a lively destination for visitors of all ages.[3][4] Founded in 1869, Santa Ana has grown from a small agricultural community into the county seat and one of the most populous cities in Orange County. Its downtown area preserves historic architecture and has evolved into a hub for arts and culture, reflecting the city's diverse heritage.[3][4] The best time to visit Santa Ana is during Peak tourist season is during the summer months (June to August), coinciding with school vacations and numerous local festivals.[3], when the weather is most pleasant for outdoor activities. For the best deals on flights from Des Moines to Santa Ana, consider booking during June and flying on Wednesday. As you plan your trip, remember to explore the local culture and indulge in Santa Ana's culinary scene.

Places to Visit in Santa Ana

Top places to visit in Santa Ana include the **Bowers Museum**, A renowned museum featuring global art and cultural exhibits, including Asian, Native American, and pre-Columbian collections. It regularly hosts special exhibitions and family-friendly activities.[1][2][5]; the **Santa Ana Zoo**, A family-oriented zoo known for its collection of monkeys, exotic birds, and interactive farm experiences for children.[1][5]; the **Lyon Air Museum**, Aviation museum featuring World War II aircraft, military vehicles, and memorabilia, located adjacent to John Wayne Airport.[1][2]; the **Downtown Santa Ana / Artists Village**, A lively arts district with galleries, theaters, boutiques, and the Grand Central Art Center. Hosts monthly ArtWalk events and features vibrant street art.[3][5]; and the **Discovery Cube Orange County**, An interactive science museum with hands-on exhibits, a 4-D theater, and educational programs for children and families.[1].

Hotels in Santa Ana

Accommodations near SNA Airport provide excellent connectivity for travelers visiting Santa Ana. Look for hotels with shuttle services and modern amenities.

Airlines Flying from Des Moines to Santa Ana

Traveling from Des Moines to Santa Ana has never been more convenient, thanks to several reputable airlines offering seamless connectivity between these vibrant cities. Airlines such as Allegiant Air, Frontier Airlines, Southwest Airlines, American Airlines provide regular flights, ensuring travelers have flexible options to suit their schedules. Typically, the flight duration is around 10-15 hours, depending on layovers and the chosen route. Most flights from Des Moines to Santa Ana include one stopover, often in major hubs, allowing for a comfortable transition. For those seeking to explore Santa Ana, booking with these airlines ensures a smooth travel experience, complete with modern amenities and excellent service.

Frequently Asked Questions

What's the lowest price for flights from Des Moines to Santa Ana?

You can find flights starting from $70. For better deals, book during June and choose Wednesday departures.

How long is the journey from Des Moines to Santa Ana?

The average flight time is about 10-15 hours, with most routes including one stopover for better pricing and comfort.

What airlines operate flights on this route?

Several airlines serve this route including Allegiant Air, Frontier Airlines, Southwest Airlines. Research current schedules and compare prices for the best deal.

How far in advance should I book?

For the best prices, book 2-3 months ahead and consider traveling during June when prices are typically lower.

What accommodation options are near SNA Airport?

SNA Airport has several nearby hotels with shuttle services, making it convenient for travelers with early or late flights.

What attractions can I visit in Santa Ana?

Santa Ana features a wonderful combination of historical sites and modern attractions. The best time to visit is during Peak tourist season is during the summer months (June to August), coinciding with school vacations and numerous local festivals.[3] for optimal sightseeing.

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