Discover affordable flights from Des Moines to San Diego with prices starting from $490. Book your journey today!
Des Moines
DSM
→
San Diego
SAN
10/15/2025 – 10/22/2025
Cheap flight deals from Des Moines to San Diego
Average price start from:
i
$110
Round-trip flights from Des Moines to San Diego starting at $110. Book now for the best deals!
One-way from:
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$69
One-way flights from Des Moines to San Diego starting at $69. Great for flexible travel!
Cheapest day:
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Wednesday
Wednesday is the cheapest day to fly from Des Moines to San Diego. Save more by booking on this day!
Cheapest In:
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$80
Mar 2025
Mar 2025 is the cheapest month to fly from Des Moines to San Diego with prices starting at $80.
Find flight deals from Des Moines to San Diego
Cheapest flights from Des Moines to San Diego
ONEWAY FLIGHTS
LAST MINUTE
CHEAP FLIGHTS
BEST FLIGHTS
Explore the cheapest oneway flights from Des Moines to San Diego spotted daily.
DSM
Des Moines
DSM - Des Moines • 2025-10-15 • 09:00
Unknown
60 min
SAN
Unknown City
$69
Non-stop • 60 min
DSM
Des Moines
DSM - Des Moines • 2025-10-15 • 09:00
Unknown
60 min
SAN
Unknown City
$75
Non-stop • 60 min
OMA
Des Moines
OMA - Des Moines • 2025-10-15 • 09:00
Unknown
60 min
SAN
Unknown City
$86
Non-stop • 60 min
CID
Des Moines
CID - Des Moines • 2025-10-15 • 09:00
Unknown
60 min
SAN
Unknown City
$145
Non-stop • 60 min
OMA
Des Moines
OMA - Des Moines • 2025-10-15 • 09:00
Unknown
60 min
SAN
Unknown City
$157
Non-stop • 60 min
OMA
Des Moines
OMA - Des Moines • 2025-10-15 • 09:00
Unknown
60 min
SAN
Unknown City
$158
Non-stop • 60 min
DSM
Des Moines
DSM - Des Moines • 2025-10-15 • 09:00
Unknown
60 min
SAN
Unknown City
$168
Non-stop • 60 min
OMA
Des Moines
OMA - Des Moines • 2025-10-15 • 09:00
Unknown
60 min
SAN
Unknown City
$169
Non-stop • 60 min
DSM
Des Moines
DSM - Des Moines • 2025-10-15 • 09:00
Unknown
60 min
SAN
Unknown City
$198
Non-stop • 60 min
OMA
Des Moines
OMA - Des Moines • 2025-10-15 • 09:00
Unknown
60 min
SAN
Unknown City
$212
Non-stop • 60 min
DSM
Des Moines
DSM - Des Moines • 2025-10-15 • 09:00
Unknown
60 min
SAN
Unknown City
$213
Non-stop • 60 min
DSM
Des Moines
DSM - Des Moines • 2025-10-15 • 09:00
Unknown
60 min
SAN
Unknown City
$235
Non-stop • 60 min
Price Trends & Analysis
Monthly Price Trends
Lowest fares from Des Moines to San Diego typically available in June.
Weather & Climate Information
Temperature
San Diego experiences a Mediterranean climate with average temperatures ranging from 50°F (10°C) in winter to 75°F (24°C) in summer, characterized by mild, wet winters and warm, dry summers. The best times for comfortable travel are during spring (March to May) and fall (September to November) when temperatures are pleasant and crowds are smaller.
Rainfall
The best time to visit San Diego is during the spring (March to May) when the weather is mild and pleasant, with fewer crowds. Additionally, you can enjoy vibrant local events like the San Diego EarthFair and the annual Comic-Con in July, but expect larger crowds during summer and early fall.
Airlines at SAN
Discover excellent flight options from Des Moines to San Diego with top airlines including Frontier Airlines, American Airlines, Delta Air Lines, United Airlines. These carriers offer reliable service and comfortable connections between these popular destinations.
The average flight time is approximately 10-15 hours, with most routes featuring one stopover for optimal pricing and convenience. When planning your journey from Des Moines to San Diego, these airlines provide excellent connectivity and modern aircraft for a pleasant travel experience.
Places to Visit in San Diego
San Diego, with its sun-kissed beaches and vibrant coastal charm, invites travelers to bask in its year-round perfect climate. Explore the historic Gaslamp Quarter, where Victorian architecture meets a lively nightlife, or wander through Balboa Park, home to world-renowned museums and lush gardens. From the thrilling sea-life encounters at La Jolla Cove to the rich heritage of Old Town, visitors can expect a captivating blend of culture, adventure, and relaxation in this enchanting Southern California paradise.
About San Diego
Embark on an exciting adventure from Des Moines to San Diego and discover a world of possibilities. This dynamic city offers a perfect mix of traditional charm and contemporary attractions. Time your visit during off-peak periods for maximum savings and comfort.
Airlines Flying from Des Moines to San Diego
Discover excellent flight options from Des Moines to San Diego with top airlines including Frontier Airlines, American Airlines, Delta Air Lines, United Airlines. These carriers offer reliable service and comfortable connections between these popular destinations.
The average flight time is approximately 10-15 hours, with most routes featuring one stopover for optimal pricing and convenience. When planning your journey from Des Moines to San Diego, these airlines provide excellent connectivity and modern aircraft for a pleasant travel experience.
Hotels in San Diego
When staying in San Diego, look for hotels with easy access to SAN Airport. Most properties provide shuttle services for seamless airport transfers.
About San Diego
Embark on an exciting adventure from Des Moines to San Diego and discover a world of possibilities. This dynamic city offers a perfect mix of traditional charm and contemporary attractions. Time your visit during off-peak periods for maximum savings and comfort.
Places to Visit in San Diego
San Diego, with its sun-kissed beaches and vibrant coastal charm, invites travelers to bask in its year-round perfect climate. Explore the historic Gaslamp Quarter, where Victorian architecture meets a lively nightlife, or wander through Balboa Park, home to world-renowned museums and lush gardens. From the thrilling sea-life encounters at La Jolla Cove to the rich heritage of Old Town, visitors can expect a captivating blend of culture, adventure, and relaxation in this enchanting Southern California paradise.
Hotels in San Diego
When staying in San Diego, look for hotels with easy access to SAN Airport. Most properties provide shuttle services for seamless airport transfers.
Airlines Flying from Des Moines to San Diego
Discover excellent flight options from Des Moines to San Diego with top airlines including Frontier Airlines, American Airlines, Delta Air Lines, United Airlines. These carriers offer reliable service and comfortable connections between these popular destinations.
The average flight time is approximately 10-15 hours, with most routes featuring one stopover for optimal pricing and convenience. When planning your journey from Des Moines to San Diego, these airlines provide excellent connectivity and modern aircraft for a pleasant travel experience.
Frequently Asked Questions
What is the cheapest flight from Des Moines to San Diego?
The cheapest fare is $69. For the best deals, consider booking during June and flying on Wednesday.
How long is the flight from Des Moines to San Diego?
Average flight time is around 10-15 hours, depending on layovers and the chosen route. Most flights include one stopover for optimal pricing.
Which airlines fly from Des Moines to San Diego?
Multiple airlines operate this route including Frontier Airlines, American Airlines, Delta Air Lines. Check current schedules and availability for the best options.
What is the best time to book flights?
Booking 2–3 months in advance usually gives the best prices. Consider flying during June for additional savings.
Are there hotels near SAN Airport?
Yes, several hotels are conveniently located near SAN Airport, including options with shuttle services for easy airport access.
What should I know about San Diego?
San Diego offers a perfect blend of culture, history, and modern attractions. The best time to visit is during pleasant weather months for optimal experiences.
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